| UniProt Protein Function: | dectin-2: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13Cellular Component: plasma membraneMolecular Function: carbohydrate bindingBiological Process: defense response to fungus; innate immune response; positive regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; stimulatory C-type lectin receptor signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q6EIG7 |
| NCBI GenInfo Identifier: | 59797926 |
| NCBI Gene ID: | 93978 |
| NCBI Accession: | Q6EIG7.1 |
| UniProt Secondary Accession: | Q6EIG7,A2RUK3 |
| UniProt Related Accession: | Q6EIG7 |
| Molecular Weight: | 20,737 Da |
| NCBI Full Name: | C-type lectin domain family 6 member A |
| NCBI Synonym Full Names: | C-type lectin domain family 6 member A |
| NCBI Official Symbol: | CLEC6AÂ Â |
| NCBI Official Synonym Symbols: | CLEC4N; CLECSF10Â Â |
| NCBI Protein Information: | C-type lectin domain family 6 member A |
| UniProt Protein Name: | C-type lectin domain family 6 member A |
| UniProt Synonym Protein Names: | C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2 |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | CLEC6AÂ Â |
| UniProt Entry Name: | CLC6A_HUMAN |
