The CLEC6A Polyclonal Antibody (PACO07212) is a valuable tool for researchers studying the CLEC6A protein, a type II transmembrane protein involved in immune responses. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to CLEC6A, it allows for the accurate detection and analysis of this protein in a variety of cell types, making it well-suited for investigations in immunology and cancer research.CLEC6A is a C-type lectin receptor known for its role in immune regulation and antigen presentation. It has been implicated in the recognition and response to pathogens, suggesting its importance in host defense mechanisms.
Research on CLEC6A has potential implications for understanding and treating diseases related to immune dysregulation, such as autoimmune disorders and infectious diseases.Furthermore, the CLEC6A Polyclonal Antibody is a valuable tool for studying the function and expression of CLEC6A in various physiological and pathological conditions. Its ability to target CLEC6A with high specificity makes it an essential resource for researchers looking to unravel the complexities of immune responses and develop novel therapeutic strategies.
Antibody Name:
CLEC6A Antibody (PACO07212)
Antibody SKU:
PACO07212
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:2000, IHC-p:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human Dectin-2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of K562 using Dectin-2 antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000.
Immunohistochemical analysis of paraffin-embedded human-heart, antibody was diluted at 1:200.
Western blot analysis of SH-SY5Y 293T using Dectin-2 antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000.
Synonyms:
CLEC6A; CLECSF10; DECTIN2; C-type lectin domain family 6 member A; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2
UniProt Protein Function:
dectin-2: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 12p13Cellular Component: plasma membraneMolecular Function: carbohydrate bindingBiological Process: defense response to fungus; innate immune response; positive regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; stimulatory C-type lectin receptor signaling pathway
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
