The CLEC4M Polyclonal Antibody (CAB14268) is designed for research involving CLEC4M, a cell surface receptor involved in immune responses and pathogen recognition. The antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications including Western blotting. It specifically binds to the CLEC4M protein, enabling researchers to detect and analyze its expression in different cell types.CLEC4M, also known as L-SIGN or CD299, plays a crucial role in immune response modulation by interacting with various pathogens and activating downstream signaling pathways. Its involvement in the recognition and uptake of pathogens highlights its importance in infectious diseases and immune system regulation.
Studying CLEC4M can provide insights into host-pathogen interactions and may lead to the development of novel therapeutic strategies for infectious diseases and immune-related disorders.Overall, the CLEC4M Polyclonal Antibody is a valuable tool for researchers in immunology, infectious diseases, and related fields who are interested in exploring the functions and mechanisms of CLEC4M in immune responses and pathogen recognition. Its high specificity and sensitivity make it an ideal choice for experiments aimed at elucidating the role of CLEC4M in health and disease.
Product Name:
CLEC4M Rabbit Polyclonal Antibody
SKU:
CAB14268
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 71-399 of human CLEC4M (NP_055072.3).
Cell membrane, Secreted, Single-pass type II membrane protein.
Calculated MW:
45kDa
Observed MW:
45kDa
This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS infection.
Purification Method:
Affinity purification
Gene ID:
10332
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of HepG2 cells, using CLEC4M antibody (CAB14268) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
