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Anti-CLEC4E Antibody (CAB20156)

SKU:
CAB20156
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MINCLE
CLECSF9
€139 - €419
Frequently bought together:

Description

Anti-CLEC4E Antibody (CAB20156)

The CLEC4E Polyclonal Antibody (CAB20156) is a valuable tool for researchers studying CLEC4E, a cell surface receptor involved in immune responses and inflammation. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it ideal for use in Western blot applications. By binding to the CLEC4E protein, this antibody enables precise detection and analysis in a variety of cell types, allowing for detailed research in immunology and cancer biology.CLEC4E, also known as C-type lectin domain family 4 member E, is a crucial player in immune regulation and inflammatory processes.

Its role in mediating immune responses makes it a promising target for research on diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of CLEC4E is essential for the development of treatments that modulate immune responses in these disease contexts, making this antibody an essential tool for researchers aiming to uncover new therapeutic strategies.

Product Name:CLEC4E Rabbit pAb
Product Code:CAB20156
Size:50uL, 100uL
Synonyms:MINCLE, CLECSF9
Applications:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human CLEC4E.
Applications:WB
Recommended Dilutions:WB 1:1000 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse spleen, Rat spleen
Immunogen:Recombinant protein of human CLEC4E.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:26253
Uniprot:Q9ULY5
Calculated MW:25kDa
Observed MW:27KDa
UniProt Protein Function:CLEC4E: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: integral to membrane; plasma membrane

Molecular Function:carbohydrate binding; receptor activity

Biological Process: defense response to bacterium; innate immune response; positive regulation of cytokine secretion; stimulatory C-type lectin receptor signaling pathway; T cell differentiation during immune response

NCBI Summary:This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
UniProt Code:Q9ULY5
NCBI GenInfo Identifier:7657333
NCBI Gene ID:26253
NCBI Accession:NP_055173.1
UniProt Secondary Accession:Q9ULY5,B2R6Q6,
UniProt Related Accession:Q9ULY5
Molecular Weight:25,073 Da
NCBI Full Name:C-type lectin domain family 4 member E
NCBI Synonym Full Names:C-type lectin domain family 4 member E
NCBI Official Symbol:CLEC4E  
NCBI Official Synonym Symbols:MINCLE; CLECSF9  
NCBI Protein Information:C-type lectin domain family 4 member E
UniProt Protein Name:C-type lectin domain family 4 member E
UniProt Synonym Protein Names:C-type lectin superfamily member 9; Macrophage-inducible C-type lectin
Protein Family:C-type lectin domain family
UniProt Gene Name:CLEC4E  
UniProt Entry Name:CLC4E_HUMAN

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