The CLEC2A Polyclonal Antibody (PAC017707) is a valuable tool for researchers studying CLEC2A, a C-type lectin-like receptor expressed on various immune cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CLEC2A protein, this antibody enables the easy detection and analysis of CLEC2A expression in different cell types, making it ideal for immunology and cancer research studies.CLEC2A is known for its role in immune regulation and its involvement in immune cell activation and signaling pathways.
By targeting CLEC2A, researchers can gain insights into its functions in inflammation, immune responses, and cell-to-cell interactions. Understanding the mechanisms of CLEC2A can provide crucial information for the development of therapies targeting immune-related diseases such as cancer, autoimmune disorders, and inflammatory conditions.Overall, the CLEC2A Polyclonal Antibody (PAC017707) offers a reliable tool for investigating the functions and activities of CLEC2A in various research areas, providing valuable insights into immune regulation and potential therapeutic targets.
Antibody Name:
CLEC2A Antibody (PACO17707)
Antibody SKU:
PACO17707
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human CLEC2A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO17707(CLEC2A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17707(CLEC2A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors
Synonyms:
C-type lectin domain family 2, member A
UniProt Protein Function:
CLEC2A: Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 12p13.31Cellular Component: integral to membrane; plasma membraneMolecular Function: protein binding; protein homodimerization activity; carbohydrate bindingBiological Process: natural killer cell mediated cytotoxicity
UniProt Protein Details:
NCBI Summary:
CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008]
