The CLEC14A Polyclonal Antibody (PAC061414) is a valuable tool for researchers studying CLEC14A, a cell surface protein involved in various cellular processes, including angiogenesis and tumor progression. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting CLEC14A in human samples, making it an ideal choice for applications such as Western blotting.By targeting the CLEC14A protein, this antibody enables researchers to investigate its role in angiogenesis and cancer development, providing important insights into potential therapeutic targets for cancer treatment.
The ability to accurately detect and analyze CLEC14A in different cell types makes this antibody a valuable resource for studies in oncology and vascular biology.With its potential implications for cancer research and angiogenesis studies, the CLEC14A Polyclonal Antibody (PAC061414) offers a reliable tool for furthering our understanding of the role of CLEC14A in disease progression and the development of targeted therapies.
Antibody Name:
CLEC14A Antibody (PACO61414)
Antibody SKU:
PACO61414
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human C-type lectin domain family 14 member A protein (278-349AA)
IHC image of PACO61414 diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Synonyms:
C-type lectin domain family 14 member A, Epidermal growth factor receptor 5, EGFR-5, CLEC14A, C14orf27, EGFR5, UNQ236/PRO269
UniProt Protein Function:
CLEC14A: Protein type: Membrane protein, integral; ProteaseChromosomal Location of Human Ortholog: 14q21.1Cellular Component: integral to membraneMolecular Function: carbohydrate binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]
