The CLEC12A Polyclonal Antibody (CAB6250) is a valuable tool for researchers studying CLEC12A, a type II transmembrane protein involved in immune regulation and cell signaling. This rabbit-derived antibody is highly specific to human samples and has been validated for use in Western blot applications. By targeting the CLEC12A protein, this antibody allows for the detection and analysis of CLEC12A expression in various cell types, making it an ideal choice for studies in immunology and cancer research.CLEC12A, also known as Dectin-1, is a C-type lectin receptor that plays a crucial role in immune response modulation and innate immunity.
It is involved in recognizing and binding to pathogen-associated molecular patterns (PAMPs) on microbes, leading to activation of immune responses. Research on CLEC12A is important for understanding its role in diseases such as cancer, infectious diseases, and inflammatory disorders, and for developing potential therapies that target this receptor.Overall, the CLEC12A Polyclonal Antibody (CAB6250) is a high-quality reagent that can help advance research in the field of immunology and contribute to the development of novel treatments for various diseases.
Product Name:
CLEC12A Rabbit Polyclonal Antibody
SKU:
CAB6250
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 66-265 of human CLEC12A (NP_612210.4).
Cell membrane, Single-pass type II membrane protein.
Calculated MW:
31kDa
Observed MW:
24kDa
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.
Purification Method:
Affinity purification
Gene ID:
160364
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from K-562 cells, using CLEC12A Rabbit pAb (CAB6250) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
