Cleaved PARP (Asp214) Polyclonal Antibody (CAB22535)
- SKU:
- CAB22535
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | Cleaved PARP (Asp214) Polyclonal Antibody |
SKU: | CAB22535 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 201-300 of Mouse PARP (Asp214) (NP_031441.2). |
Sequence: | AIKN EGKR KGDE VDGT DEVA KKKS KKGK DKDS SKLE KALK AQNE LIWN IKDE LKKA CSTN DLKE LLIF NQQQ VPSG ESAI LDRV ADGM AFGA LLPC KECS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | PARP; PPOL; ARTD1; Adprp; Adprt1; msPARP; parp-1; sPARP-1; 5830444G22Rik; Cleaved PARP (Asp214) |
Positive Sample: | NIH/3T3+Staurosporine |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, mitochondrion, nuclear body, nuclear envelope, nuclear replication fork, nucleolus |
Calculated MW: | 113kDa |
Observed MW: | 89kDa |
Enables NAD+ ADP-ribosyltransferase activity; chromatin binding activity; and protein ADP-ribosylase activity. Involved in negative regulation of telomere maintenance via telomere lengthening; positive regulation of single strand break repair; and voluntary musculoskeletal movement. Acts upstream of or within several processes, including DNA metabolic process; behavioral response to cocaine; and protein poly-ADP-ribosylation. Located in cytoplasm; nucleolus; and nucleoplasm. Part of protein-containing complex. Is expressed in several structures, including Peyer's patch; brain; gut; immune system; and retina. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1).
Purification Method: | Affinity purification |
Gene ID: | 11545 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |