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Cleaved-MMP27 (Y99) Antibody (PACO00037)

SKU:
PACO00037
Product Type:
Antibody
Reactivity:
Human
NHP - Monkey
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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Cleaved-MMP27 (Y99) Antibody (PACO00037)

The Cleaved MMP27 (Y99) Antibody (PACO00037) is a highly specific and sensitive tool for researchers studying matrix metalloproteinase 27 (MMP27) cleavage events. This polyclonal antibody, raised in rabbits, is validated for use in various applications, including Western blotting and immunohistochemistry. It recognizes the cleaved form of MMP27 at tyrosine 99, enabling precise detection and analysis of this critical protein in cell and tissue samples.MMP27 is a member of the matrix metalloproteinase family, known for its role in extracellular matrix degradation and tissue remodeling. The cleavage of MMP27 at tyrosine 99 is associated with specific signaling events and cellular processes, making it a crucial target for investigation in cancer biology, inflammation, and other disease states.

By using the Cleaved MMP27 (Y99) Antibody, researchers can gain valuable insights into the regulation and function of MMP27 in various physiological and pathological conditions.Overall, the Cleaved MMP27 (Y99) Antibody is a valuable tool for researchers seeking to understand the complex mechanisms involving MMP27 cleavage and its implications in disease progression and therapeutic interventions. Its high specificity and sensitivity make it a reliable choice for studies in cancer research, inflammation, and other fields where MMP27 is known to play a critical role.

Antibody Name:Cleaved-MMP27 (Y99) Antibody
Antibody SKU:PACO00037
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Monkey
Immunogen:synthesized peptide derived from the Internal region of human MMP-27.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:MMP27; Matrix metalloproteinase-27; MMP-27
UniProt Protein Function:MMP27: Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens. Belongs to the peptidase M10A family.
UniProt Protein Details:

Protein type:EC 3.4.24.-; Secreted; Secreted, signal peptide; Protease

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: extracellular matrix

Molecular Function:zinc ion binding; metalloendopeptidase activity; calcium ion binding

Biological Process: collagen catabolic process; proteolysis

NCBI Summary:Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. [provided by RefSeq, Jul 2008]
UniProt Code:Q9H306
NCBI GenInfo Identifier:296437372
NCBI Gene ID:64066
NCBI Accession:Q9H306.2
UniProt Secondary Accession:Q9H306,Q6UWK6,
UniProt Related Accession:Q9H306
Molecular Weight:513
NCBI Full Name:Matrix metalloproteinase-27
NCBI Synonym Full Names:matrix metallopeptidase 27
NCBI Official Symbol:MMP27  
NCBI Official Synonym Symbols:MMP-27  
NCBI Protein Information:matrix metalloproteinase-27; matrix metalloprotease 27; matrix metalloproteinase 27
UniProt Protein Name:Matrix metalloproteinase-27
Protein Family:Matrix metalloproteinase
UniProt Gene Name:MMP27  
UniProt Entry Name:MMP27_HUMAN

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