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Cleaved-MMP23A (Y79) Antibody (PACO00036)

SKU:
PACO00036
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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Cleaved-MMP23A (Y79) Antibody (PACO00036)

The Cleaved MMP23A (Y79) Antibody (PAC00036) is a valuable tool for researchers studying matrix metalloproteinase 23A (MMP23A), a protease involved in extracellular matrix remodeling and cell signaling. This antibody targets the specific cleaved form of MMP23A at the Y79 site, allowing for precise detection and analysis in various experimental settings.Raised in rabbits, this polyclonal antibody is highly reactive with human samples and has been validated for use in applications such as Western blotting. Its specificity for the Y79 cleavage site of MMP23A makes it a crucial tool for investigating the role of MMP23A in processes such as cell migration, tissue remodeling, and cancer progression.

By using the Cleaved MMP23A (Y79) Antibody (PAC00036), researchers can gain valuable insights into the function and regulation of MMP23A in various biological contexts, including cancer research, wound healing, and inflammation. This antibody is a powerful tool for unraveling the complex mechanisms underlying MMP23A activity and its potential as a therapeutic target in diseases characterized by dysregulated extracellular matrix remodeling.

Antibody Name:Cleaved-MMP23A (Y79) Antibody
Antibody SKU:PACO00036
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human MMP-23.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:MMP23A; MMP21; MMP23B; MMP21; MMP22; Matrix metalloproteinase-23; MMP-23; Femalysin; MIFR-1; Matrix metalloproteinase-21; MMP-21; Matrix metalloproteinase-22; MMP-22
UniProt Protein Function:MMP23B: Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum. Belongs to the peptidase M10A family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; EC 3.4.24.-; Protease

Chromosomal Location of Human Ortholog: 1p36.3

Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum membrane; integral to membrane; intracellular

Molecular Function:zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: proteolysis; reproduction

NCBI Summary:This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]
UniProt Code:O75900
NCBI GenInfo Identifier:117949605
NCBI Gene ID:8510
NCBI Accession:O75900.2
UniProt Secondary Accession:O75900,O75894, O75895, Q5QPQ8, Q76P96, Q7LDM6, Q7LDM7 Q9UBR9, Q9UJK8, A2AGN0, A2AGN1,
UniProt Related Accession:O75900
Molecular Weight:46,305 Da
NCBI Full Name:Matrix metalloproteinase-23
NCBI Synonym Full Names:matrix metallopeptidase 23B
NCBI Official Symbol:MMP23B  
NCBI Official Synonym Symbols:MIFR; MMP22; MIFR-1; MMP23A  
NCBI Protein Information:matrix metalloproteinase-23; MMP-21; MMP-22; MMP-23; femalysin; matrix metalloproteinase 22; matrix metalloproteinase 23B; matrix metalloproteinase in the female reproductive tract; matrix metalloproteinase-21; matrix metalloproteinase-22
UniProt Protein Name:Matrix metalloproteinase-23
UniProt Synonym Protein Names:Femalysin; MIFR-1; Matrix metalloproteinase-21; MMP-21; Matrix metalloproteinase-22; MMP-22
UniProt Gene Name:MMP23A  
UniProt Entry Name:MMP23_HUMAN

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