The Cleaved ITIH2-D702 Polyclonal Antibody (PACO00051) is a valuable tool for researchers studying the cleaved form of the inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2-D702). This antibody, generated in rabbits, has high specificity and reactivity towards human samples, making it suitable for various research applications such as Western blot analysis.ITIH2 is a protein involved in extracellular matrix stabilization and has been implicated in a variety of physiological processes including inflammation, cancer, and tissue repair.
The cleaved form, ITIH2-D702, has been shown to have specific functions and may serve as a biomarker for certain diseases.By using the Cleaved ITIH2-D702 Polyclonal Antibody, researchers can detect and quantify the cleaved form of ITIH2 in different cell types and tissues, providing valuable insights into its role in various biological processes. This antibody is a valuable tool for studies investigating the molecular mechanisms underlying disease pathology and potential therapeutic interventions.
Antibody Name:
Cleaved-ITIH2 (D702) Antibody
Antibody SKU:
PACO00051
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human ITI-H2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ITIH2; IGHEP2; Inter-alpha-trypsin inhibitor heavy chain H2; ITI heavy chain H2; ITI-HC2; Inter-alpha-inhibitor heavy chain 2; Inter-alpha-trypsin inhibitor complex component II; Serum-derived hyaluronan-associated protein; SHAP
UniProt Protein Function:
ITIH2: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Belongs to the ITIH family.Protein type: Secreted, signal peptide; Secreted; InhibitorChromosomal Location of Human Ortholog: 10p15Molecular Function: endopeptidase inhibitor activity
UniProt Protein Details:
NCBI Summary:
The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]
