The Cleaved GGT7 (T472) Antibody (PACO03860) is a specialized tool for researchers studying GGT7, a key enzyme involved in glutathione metabolism and cellular detoxification processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting cleaved GGT7 protein in human samples. Validated for use in Western blot applications, it allows for precise and accurate analysis of GGT7 cleavage in various cell types.GGT7 is a critical player in maintaining cellular redox balance and protecting cells from oxidative stress-induced damage. Dysregulation of GGT7 activity has been implicated in various disease states, including cancer, neurodegenerative disorders, and metabolic diseases.
By targeting cleaved GGT7, researchers can gain insights into the dynamics of GGT7 function and its potential role in disease progression.Investigating the cleavage of GGT7 with this antibody can provide valuable information for understanding the biochemical mechanisms underlying cellular detoxification and redox signaling pathways. This knowledge may pave the way for developing novel therapeutic strategies aimed at targeting GGT7 cleavage for the treatment of diseases characterized by oxidative stress and impaired cellular homeostasis.
Antibody Name:
Cleaved-GGT7 (T472) Antibody
Antibody SKU:
PACO03860
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human GGT4 HC.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
GGTL3: Cleaves glutathione conjugates. Belongs to the gamma-glutamyltransferase family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Other Amino Acids Metabolism - taurine and hypotaurine; Other Amino Acids Metabolism - glutathione; Lipid Metabolism - arachidonic acid; Other Amino Acids Metabolism - cyanoamino acid; EC 2.3.2.2; Transferase; EC 3.4.19.13; Membrane protein, integral; Other Amino Acids Metabolism - selenoamino acidChromosomal Location of Human Ortholog: 20q11.22Cellular Component: anchored to external side of plasma membraneMolecular Function: gamma-glutamyltransferase activity; protein bindingBiological Process: glutathione metabolic process; leukotriene biosynthetic process
UniProt Protein Details:
NCBI Summary:
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008]
