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Cleaved Gasdermin D (N Terminal) Rabbit Monoclonal Antibody (CAB24059)

SKU:
CAB24059
Product Type:
Antibody
Host Species:
Rabbit
Size:
20uL
Isotype:
IgG
€129
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Description

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Cleaved Gasdermin D (N Terminal) Rabbit Monoclonal Antibody (CAB24059)

The Cleaved Gasdermin-D N-Terminal Rabbit Monoclonal Antibody (CAB24059) is a cutting-edge tool for researchers studying pyroptosis, a highly inflammatory form of cell death. This antibody, developed using high-quality rabbit monoclonal technology, specifically targets the N-terminal fragment of cleaved Gasdermin-D. It has been validated for use in Western blot and immunofluorescence applications, allowing for precise detection and visualization of cleaved Gasdermin-D in various cell types.Gasdermin-D is a key player in the process of pyroptosis, a programmed cell death pathway that is triggered by inflammatory signals. By targeting the N-terminal fragment of cleaved Gasdermin-D, this antibody enables researchers to investigate the mechanisms underlying pyroptosis and its role in inflammatory responses.

Its high specificity and sensitivity make it an essential tool for studies on immune response, infection, and inflammation.Researchers in immunology, cell biology, and disease pathology will find the Cleaved Gasdermin-D N-Terminal Rabbit Monoclonal Antibody (CAB24059) invaluable for advancing their research on pyroptosis and its implications in various diseases, including infectious diseases, autoimmune disorders, and cancer. Its ability to target a specific fragment of Gasdermin-D provides a detailed insight into the complex pathways involved in cell death and inflammation, paving the way for new therapeutic approaches targeting pyroptosis-related conditions.

Product Name: Cleaved Gasdermin D (N Terminal) Rabbit Monoclonal Antibody
SKU: CAB24059
Size: 20uL
Isotype: IgG
Host Species: Rabbit
Reactivity: Human
Immunogen: A synthetic peptide corresponding to residues surrounding Asp275 of human Gasdermin D(NP_079012.3).
Sequence: NFLTD
Tested Applications: WBELISA
Recommended Dilution: WB: 1:500 - 1:1000
Synonyms: DF5L; DFNA5L; FKSG10; GSDMDC1
Positive Sample: THP-1 treated by LPS and Nigericin
Conjugate: Unconjugated
Cellular Localization: Cytosol, Extracellular region, Extracellular space, NLRP3 inflammasome complex, Nucleoplasm, Plasma membrane
Calculated MW: 53kDa
Observed MW: 31kDa

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.

Purification Method: Affinity purification
Gene ID: 79792
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product Image Western blot analysis of lysates from THP-1 cells using Cleaved GSDMD (N Terminal) mAb (CAB24059) at 1:1000 dilution. THP-1 cells were treated by LPS and Nigericin. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.
Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020).
Exposure time: 10s.

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