Cleaved Gasdermin B (C Terminal) Monoclonal Antibody (CAB24342)
The Cleaved Gasdermin B C-Terminal Monoclonal Antibody is a specialized research tool designed for the detection and analysis of cleaved Gasdermin B, a key player in pyroptosis, a highly inflammatory form of programmed cell death. This antibody, produced through monoclonal antibody technology, is highly specific and reactive with cleaved Gasdermin B in human samples, providing researchers with a reliable tool for Western blot applications.Gasdermin B is a critical mediator of pyroptosis, a process that leads to the release of pro-inflammatory cytokines and cell death. Understanding the cleavage and activation of Gasdermin B is essential for studying inflammatory pathways and developing targeted therapies for conditions such as infectious diseases and inflammatory disorders.
By utilizing the Cleaved Gasdermin B C-Terminal Monoclonal Antibody, researchers can gain valuable insights into the activation and function of Gasdermin B, furthering our understanding of pyroptosis and its role in immune responses. This antibody is an essential tool for studies in immunology, microbiology, and cell biology, providing a comprehensive approach to investigating pyroptosis and its implications in health and disease.
Product Name:
Cleaved Gasdermin B (C Terminal) Monoclonal Antibody
SKU:
CAB24342
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to residues surrounding Ser245 of human Gasdermin B (NP_001159430.1).
GSDMB-C-6-his, 293T GSDMB stable cells transfected with GZMA
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm
Calculated MW:
18kDa/45kDa/46kDa/47kDa
Observed MW:
16kDa
This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.
Purification Method:
Affinity purification
Gene ID:
55876
Clone Number:
ARC63400
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from GSDMB-C-6-his protein, using Cleaved Gasdermin B（C Terminal） Rabbit mAb (CAB24342) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 0.3s.WB samples for antibody validation are kindly provided by Dr. Feng Shao, NIBS
