F12 Rabbit Polyclonal Antibody (CAB1691)
- SKU:
- CAB1691
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | F12 Rabbit Polyclonal Antibody |
SKU: | CAB1691 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 336-615 of human F12 (NP_000496.2). |
Sequence: | QTPG ALPA KREQ PPSL TRNG PLSC GQRL RKSL SSMT RVVG GLVA LRGA HPYI AALY WGHS FCAG SLIA PCWV LTAA HCLQ DRPA PEDL TVVL GQER RNHS CEPC QTLA VRSY RLHE AFSP VSYQ HDLA LLRL QEDA DGSC ALLS PYVQ PVCL PSGA ARPS ETTL CQVA GWGH QFEG AEEY ASFL QEAQ VPFL SLER CSAP DVHG SSIL PGML CAGF LEGG TDAC QGDS GGPL VCED QAAE RRLT LQGI ISWG SGCG DRNK PGVY TDVA YYLA WIRE HTVS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | HAF; HAE3; HAEX; F12 |
Positive Sample: | HepG2,MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 68kDa |
Observed MW: | 50kDa |
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
Purification Method: | Affinity purification |
Gene ID: | 2161 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |