The CLDN2 Antibody (PAC021014) is a vital tool for researchers studying the role of claudin-2, a tight junction protein that plays a key role in the regulation of paracellular permeability. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting claudin-2 in human samples, making it a reliable choice for Western blot applications.Claudin-2 is known to be involved in various physiological and pathological processes, including the maintenance of barrier function in epithelial tissues and the progression of certain cancers.
By targeting claudin-2 with this antibody, researchers can gain valuable insights into how this protein contributes to disease development and progression, paving the way for potential therapeutic interventions in conditions such as inflammatory bowel disease and cancer metastasis.Overall, the CLDN2 Antibody (PAC021014) represents a valuable tool for researchers seeking to explore the functional significance of claudin-2 in health and disease, offering reliable and accurate detection capabilities for a wide range of experimental applications.
Gel: 12%SDS-PAGE, Lysate: 40 µg, Lane 1-4: Hela, 293T, PC3 and TM4 cell, Primary antibody: PACO21014(CLDND2 Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO21014(CLDND2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
CLDND2 (claudin domain containing 2) is a 167 amino acid, multi-pass membrane protein that belongs to the PMP-22/EMP/MP20 family and is encoded by a gene that maps to human chromosome 19q13.33. Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes.
