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CLDN9 Antibody (PACO13753)

SKU:
PACO13753
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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CLDN9 Antibody (PACO13753)

The CLDN9 Polyclonal Antibody (PAC013753) is a valuable tool for researchers studying CLDN9, a member of the claudin family of tight junction proteins that play a crucial role in maintaining the integrity of epithelial barriers. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the CLDN9 protein, the antibody enables researchers to detect and analyze CLDN9 in various cell types, making it an ideal choice for studies in cell biology, epithelial barrier function, and cancer research.CLDN9 is known to be involved in the regulation of paracellular permeability, cell signaling, and cell adhesion, making it a key player in the maintenance of tissue homeostasis and barrier function.

Dysregulation of CLDN9 has been linked to various diseases, including cancer, inflammatory bowel diseases, and autoimmune disorders. By understanding the role of CLDN9 in these conditions, researchers can develop potential therapeutic strategies targeting tight junction proteins for the treatment of these diseases.In summary, the CLDN9 Polyclonal Antibody is a valuable tool for researchers interested in studying the function of CLDN9 in health and disease. Its high specificity and reactivity with human samples make it a reliable option for Western blot applications and other research techniques aimed at unraveling the molecular mechanisms involving tight junction proteins in various pathological conditions.

Antibody Name:CLDN9 Antibody (PACO13753)
Antibody SKU:PACO13753
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human CLDN9-specific
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:claudin 9;
UniProt Protein Function:Claudin-9: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: tight junction; plasma membrane; integral to membrane

Molecular Function:identical protein binding; structural molecule activity

Biological Process: intercellular junction assembly and maintenance; viral reproduction; calcium-independent cell-cell adhesion

NCBI Summary:This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein is one of the entry cofactors for hepatitis C virus. Mouse studies revealed that this gene is required for the preservation of sensory cells in the hearing organ and the gene deficiency is associated with deafness. [provided by RefSeq, Jun 2010]
UniProt Code:O95484
NCBI GenInfo Identifier:6685303
NCBI Gene ID:9080
NCBI Accession:O95484.1
UniProt Related Accession:O95484
Molecular Weight:Calculated MW 23kDa Observed MW 25-29kDa
NCBI Full Name:Claudin-9
NCBI Synonym Full Names:claudin 9
NCBI Official Symbol:CLDN9  
NCBI Protein Information:claudin-9
UniProt Protein Name:Claudin-9
Protein Family:Claudin
UniProt Gene Name:CLDN9  
UniProt Entry Name:CLD9_HUMAN

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