The CLDN4 Polyclonal Antibody (CAB12912) is a valuable tool for researchers studying CLDN4, a member of the claudin family of proteins that plays a crucial role in tight junction formation and function. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in Western blotting and immunohistochemistry applications.CLDN4 is known to be involved in the regulation of epithelial barrier function and the maintenance of tissue integrity, making it a target of interest in various research fields, including cancer biology and gastrointestinal diseases.
By targeting CLDN4 with this antibody, researchers can investigate the expression and localization of this protein in different cell types and tissues, providing valuable insights into its role in physiological and pathological conditions.With its high specificity and sensitivity, the CLDN4 Polyclonal Antibody (CAB12912) offers researchers a reliable tool for studying the function and regulation of CLDN4 in various experimental settings, ultimately leading to a better understanding of its potential implications in health and disease.
Product Name:
CLDN4 Rabbit Polyclonal Antibody
SKU:
CAB12912
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 109-209 of human CLDN4 (NP_001296.1).
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
Purification Method:
Affinity purification
Gene ID:
1364
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CLDN4 Rabbit pAb (CAB12912) at 1:4000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC): HL-60Exposure time: 30s.
