CLDN23 Antibody (PACO14276)
- SKU:
- PACO14276
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | CLDN23 Antibody (PACO14276) |
| Antibody SKU: | PACO14276 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human CLDN23 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: PACO14276(CLDN23 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14276(CLDN23 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. |
| Synonyms: | claudin 23 |
| UniProt Protein Function: | Claudin-23: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Belongs to the claudin family.Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cell adhesionChromosomal Location of Human Ortholog: 8p23.1Cellular Component: tight junctionMolecular Function: identical protein bindingBiological Process: calcium-independent cell-cell adhesion |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010] |
| UniProt Code: | Q96B33 |
| NCBI GenInfo Identifier: | 47605532 |
| NCBI Gene ID: | 137075 |
| NCBI Accession: | Q96B33.2 |
| UniProt Secondary Accession: | Q96B33,Q08AJ3 |
| UniProt Related Accession: | Q96B33 |
| Molecular Weight: | 31,915 Da |
| NCBI Full Name: | Claudin-23 |
| NCBI Synonym Full Names: | claudin 23 |
| NCBI Official Symbol: | CLDN23Â Â |
| NCBI Official Synonym Symbols: | CLDNL; hCG1646163Â Â |
| NCBI Protein Information: | claudin-23 |
| UniProt Protein Name: | Claudin-23 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN23Â Â |
| UniProt Entry Name: | CLD23_HUMAN |
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