CLDN20 Antibody (PACO25789)
- SKU:
- PACO25789
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CLDN20 Antibody (PACO25789)
The CLDN20 Polyclonal Antibody (PACO25789) is a valuable tool for researchers studying the functions of CLDN20, a member of the claudin family of proteins involved in tight junction formation and regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CLDN20 protein, this antibody enables the detection and analysis of CLDN20 expression in a variety of cell types.CLDN20 plays a crucial role in the maintenance of epithelial barrier function and the regulation of paracellular permeability.
Dysregulation of CLDN20 has been linked to various pathological conditions, including cancer progression and inflammatory diseases. Therefore, studying the expression and function of CLDN20 is essential for understanding its role in disease pathogenesis and developing targeted therapeutics.In conclusion, the CLDN20 Polyclonal Antibody (PACO25789) is a valuable research tool for investigating the functions of CLDN20 in various physiological and pathological processes. Its high reactivity and specificity make it an ideal choice for studies in cell biology, cancer research, and epithelial barrier function.
| Antibody Name: | CLDN20 Antibody (PACO25789) |
| Antibody SKU: | PACO25789 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Claudin-20 protein (29-81AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: CLDN20 antibody at 4µg/ml Lane 1: A549 whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: PC-3 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 24 kDa Observed band size: 24 kDa . |
 | Immunofluorescent analysis of HepG2 cells using PACO25789 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. |
| Synonyms: | Claudin-20, CLDN20 |
| UniProt Protein Function: | Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.Subcellular location: Cell junction › tight junction. Cell membrane; Multi-pass membrane protein. Sequence similarities: Belongs to the claudin family. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P56880 |
| NCBI GenInfo Identifier: | 7387580 |
| NCBI Gene ID: | 49861 |
| NCBI Accession: | P56880.1 |
| UniProt Secondary Accession: | P56880 |
| UniProt Related Accession: | P56880 |
| Molecular Weight: | 23,515 Da |
| NCBI Full Name: | Claudin-20 |
| NCBI Synonym Full Names: | claudin 20 |
| NCBI Official Symbol: | CLDN20Â Â |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | claudin-20 |
| UniProt Protein Name: | Claudin-20 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN20Â Â |
| UniProt Entry Name: | CLD20_HUMAN |
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