Claudin18.2 Monoclonal Antibody (CAB20420)
- SKU:
- CAB20420
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CLDN18
- SFTA5
- SFTPJ
- Research Area:
- Cell Biology
Description
| Product Name: | Claudin18.2 Monoclonal Antibody |
| SKU: | CAB20420 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN18.2 (P56856-2). |
| Sequence: | MSTT TCQV VAFL LSIL GLAG CIAA TGMD MWST QDLY DNPV TSVF QYEG LWRS CVRQ SSGF TECR PYFT ILGL PAML QAVR ALMI VGIV LGAI GLLV SIFA |
| Tested Applications: | IHC-P ELISA |
| Recommended Dilution: | IHC-P,1:50 - 1:200 |
| Synonyms: | SFTA5; SFTPJ; Claudin18.2 |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction. |
| Calculated MW: | 28kDa |
| Observed MW: | Refer to figures |
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
| Purification Method: | Affinity purification |
| Gene ID: | 51208 |
| Clone Number: | ARC5062-02 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |
 | Immunohistochemistry analysis of paraffin-embedded human stomach using CLDN18.2 Rabbit mAb (CAB20420) at dilution of 1:50 (40x lens).Perform high pressure antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
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