The CLDN17 Polyclonal Antibody (CAB15151) is a valuable tool for researchers studying CLDN17, a tight junction protein involved in cell-cell adhesion and barrier function. This antibody, generated in rabbits, shows high specificity and sensitivity for human samples, making it ideal for Western blot applications. By targeting the CLDN17 protein, this antibody allows for the detection and analysis of CLDN17 expression in various cell types, facilitating investigations in areas such as epithelial biology and cancer research.
CLDN17 is a key player in maintaining the integrity of epithelial barriers, making it essential for the proper function of tissues like the skin and gastrointestinal tract. Dysregulation of CLDN17 has been implicated in various pathological conditions, including inflammatory bowel disease and cancer metastasis. By gaining insights into the role of CLDN17, researchers can uncover new therapeutic targets and potential treatment strategies for these diseases.
Product Name:
CLDN17 Rabbit Polyclonal Antibody
SKU:
CAB15151
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human CLDN17 (NP_036263.1).
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11.
Purification Method:
Affinity purification
Gene ID:
26285
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CLDN17 Rabbit pAb (CAB15151) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
