The CLDN15 Polyclonal Antibody (PACO25785) is designed for research involving CLDN15, a crucial component of tight junctions in epithelial cells. The antibody, generated in rabbits, shows high specificity for CLDN15 and is validated for use in immunohistochemistry and immunofluorescence applications. It binds to the CLDN15 protein, allowing for precise detection and localization in various tissues, making it an ideal tool for studying epithelial barrier function and related diseases.CLDN15, a member of the claudin family, is essential for maintaining the integrity of tight junctions and regulating paracellular transport in epithelial barriers. Its role in controlling permeability and cell-cell adhesion makes it a key player in various physiological processes, including nutrient absorption, fluid homeostasis, and protection against pathogens.
Dysfunction of CLDN15 has been associated with conditions such as inflammatory bowel disease, celiac disease, and certain types of cancer, highlighting its potential as a therapeutic target.By investigating the expression and function of CLDN15 with the PACO25785 antibody, researchers can gain insights into the mechanisms underlying epithelial barrier regulation and identify novel strategies for treating disorders characterized by impaired barrier function. This antibody is a valuable tool for advancing our understanding of epithelial biology and developing targeted therapies for a range of gastrointestinal and autoimmune diseases.
