The CLDN11 Polyclonal Antibody (CAB12478) is a valuable tool for researchers studying CLDN11, a tight junction protein that plays a crucial role in maintaining the blood-brain barrier and regulating the movement of molecules across cell barriers. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in various applications including Western blot and immunohistochemistry.CLDN11 is essential for the formation and maintenance of tight junctions in the central nervous system, making it a key player in neurological diseases such as multiple sclerosis and brain tumors.
By targeting CLDN11 with this antibody, researchers can gain insights into the role of tight junction proteins in disease pathogenesis and potentially develop novel therapeutic strategies.With its high reactivity and specificity, the CLDN11 Polyclonal Antibody (CAB12478) is a valuable tool for researchers investigating the biology of tight junction proteins and their implications for neurological disorders. It is an essential reagent for studies aiming to understand the molecular mechanisms underlying blood-brain barrier function and dysfunction.
Product Name:
CLDN11 Rabbit Polyclonal Antibody
SKU:
CAB12478
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN11 (NP_005593.2).
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
5010
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CLDN11 antibody (CAB12478) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
