The CLCN1 Monoclonal Antibody is a valuable tool for researchers studying the CLCN1 gene, which encodes a chloride channel protein involved in muscle function. This antibody, generated in a mouse host, exhibits high specificity and sensitivity for detecting CLCN1 protein in human samples, making it ideal for Western blotting applications.The CLCN1 protein plays a crucial role in muscle contraction and relaxation by regulating chloride ion flux across the muscle cell membrane. Dysregulation of CLCN1 function has been implicated in muscle disorders such as myotonia congenita and Becker's disease.
By targeting the CLCN1 protein, researchers can gain insights into the molecular mechanisms underlying these conditions and develop potential therapeutic interventions.Overall, the CLCN1 Monoclonal Antibody is a reliable tool for investigating the role of CLCN1 in muscle physiology and pathological conditions related to chloride channel dysfunction. Its specificity and sensitivity make it an essential component of studies aiming to unravel the complexities of muscle disorders and explore potential treatments.
Product Name:
CLCN1 Monoclonal Antibody
SKU:
CAB21237
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 889-988 of human CLCN1 (NP_000074.3).
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1180
Clone Number:
ARC52491
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CLCN1 antibody (CAB21237) at 1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
