The Claudin-7 Polyclonal Antibody (CAB2035) is a vital tool for researchers studying Claudin-7, a crucial protein involved in maintaining the integrity of tight junctions in epithelial cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting and immunohistochemistry.Claudin-7 is a key player in regulating the permeability of tight junctions, which are essential for controlling the movement of molecules across epithelial barriers. Dysregulation of Claudin-7 has been implicated in various diseases, including cancer and inflammatory bowel disease.
By targeting Claudin-7 with this antibody, researchers can study its expression levels and localization in different cell types, providing valuable insights into its role in epithelial barrier function.Understanding the function of Claudin-7 is crucial for developing targeted therapies that aim to restore tight junction integrity in disease conditions. The Claudin-7 Polyclonal Antibody is a valuable tool for researchers interested in unraveling the mechanisms underlying epithelial barrier dysfunction and exploring novel treatment strategies for related diseases.
Product Name:
CLDN7 Rabbit Polyclonal Antibody
SKU:
CAB2035
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 29-211 of human CLDN7 (NP_001298.3).
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.
Purification Method:
Affinity purification
Gene ID:
1366
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse large intestine using CLDN7 Rabbit pAb(CAB2035) at 1:2000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:25s.
