The Claudin-6 Monoclonal Antibody is a vital tool for researchers studying Claudin-6, a key protein involved in cell-to-cell adhesion and barrier function. This antibody, produced using cutting-edge monoclonal antibody technology, specifically targets Claudin-6 in human samples and is suitable for various research applications, including immunofluorescence, immunohistochemistry, and flow cytometry.Claudin-6 is a critical component of tight junctions, which are essential for maintaining the integrity of epithelial barriers in various tissues. Dysregulation of Claudin-6 has been linked to various diseases, including cancer and inflammatory disorders.
By utilizing the Claudin-6 Monoclonal Antibody, researchers can gain valuable insights into the role of Claudin-6 in disease pathogenesis and potentially develop targeted therapies for conditions involving dysregulated Claudin-6 expression.Overall, the Claudin-6 Monoclonal Antibody is a highly specific and reliable tool for studying Claudin-6 in various research settings, offering researchers the opportunity to deepen their understanding of tight junction biology and its implications for human health and disease.
Product Name:
Claudin 6 Monoclonal Antibody
SKU:
CAB24011
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 119-219 of human Claudin 6(NP_067018.2)
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
Purification Method:
Affinity purification
Gene ID:
9074
Clone Number:
ARC63026
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Claudin 6 Rabbit mAb (CAB24011) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
