The Claudin-5 Polyclonal Antibody (CAB10207) is a valuable tool for researchers studying the tight junction protein Claudin-5, which plays a key role in maintaining the blood-brain barrier and regulating paracellular permeability in endothelial cells. This antibody, produced in rabbits, specifically targets Claudin-5 in human samples and is validated for use in various applications, including immunofluorescence and immunohistochemistry.Claudin-5 is essential for maintaining the integrity of the blood-brain barrier, which is crucial for protecting the central nervous system from harmful substances and pathogens.
Dysregulation of Claudin-5 has been implicated in various neurological disorders, including multiple sclerosis, Alzheimer's disease, and stroke. Therefore, studying the expression and localization of Claudin-5 using this antibody can provide valuable insights into the mechanisms underlying these conditions and may lead to the development of novel therapeutic strategies targeting the blood-brain barrier.
Product Name:
CLDN5 Rabbit Polyclonal Antibody
SKU:
CAB10207
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 119-218 of human CLDN5 (NP_001349995.1).
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
7122
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CLDN5 Rabbit pAb (CAB10207) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
