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Claudin 1 Monoclonal Antibody (CAB21971)

SKU:
CAB21971
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
€139 - €529
Frequently bought together:

Description

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Product Name:Claudin 1 Monoclonal Antibody
SKU:CAB21971
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 112-211 of human Claudin 1 (NP_066924.1).
Sequence:EVQK MRMA VIGG AIFL LAGL AILV ATAW YGNR IVQE FYDP MTPV NARY EFGQ ALFT GWAA ASLC LLGG ALLC CSCP RKTT SYPT PRPY PKPA PSSG KDYV
Tested Applications:WB ELISA
Recommended Dilution:WB,1:1000 - 1:5000
Synonyms:CLD1; SEMP1; ILVASC; 1
Positive Sample:A-431,Hep G2,Mouse liver,Mouse kidney,Rat kidney
Conjugate:Unconjugated
Cellular Localization:Cell junction, Cell membrane, Multi-pass membrane protein, tight junction.
Calculated MW:23kDa
Observed MW:20kDa

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Purification Method:Affinity purification
Gene ID:9076
Clone Number:ARC54475
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using [KO Validated] Claudin 1 Rabbit mAb (CAB21971) at1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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