CKMT1A Rabbit Polyclonal Antibody (CAB5233)
- SKU:
- CAB5233
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | CKMT1A Rabbit Polyclonal Antibody |
SKU: | CAB5233 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 258-417 of human CKMT1A (NP_001015001.1). |
Sequence: | FLIW VNEE DHTR VISM EKGG NMKR VFER FCRG LKEV ERLI QERG WEFM WNER LGYI LTCP SNLG TGLR AGVH IKLP LLSK DSRF PKIL ENLR LQKR GTGG VDTA ATGG VFDI SNLD RLGK SEVE LVQL VIDG VNYL IDCE RRLE RGQD IRIP TPVI HTKH |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CKMT1; U-MtCK; mia-CK; CKMT1A |
Positive Sample: | Mouse heart,Rat heart,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Intermembrane side, Mitochondrion inner membrane, Peripheral membrane protein. |
Calculated MW: | 47kDa |
Observed MW: | 47kDa |
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.
Purification Method: | Affinity purification |
Gene ID: | 548596 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |