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CKMT1A Monoclonal Antibody [PAT17A2AT] (CPAB0186)

SKU:
CPAB0186
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
€149

Description

system_update_alt Datasheet

CKMT1A Monoclonal Antibody [PAT17A2AT] (CPAB0186)

The CKMT1A Polyclonal Antibody (CPAB0186) is a valuable tool for research involving CKMT1A, a key enzyme involved in cellular energy metabolism. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CKMT1A protein, this antibody allows for the detection and analysis of CKMT1A in a variety of cell types, making it an ideal choice for studies in metabolic disorders, mitochondrial dysfunction, and cardiovascular diseases.

CKMT1A, also known as mitochondrial creatine kinase, plays a crucial role in maintaining cellular energy homeostasis by facilitating the transfer of high-energy phosphate groups within the mitochondria. Dysregulation of CKMT1A activity has been linked to various pathological conditions, including cardiac hypertrophy, heart failure, and neurodegenerative diseases. Investigating the function of CKMT1A is essential for understanding the underlying mechanisms of these disorders and developing targeted therapies to address them.

Product Name:CKMT1A Antibody
Product Sku:CPAB0186
Size:5μg
Host Species:Mouse IgG2b
Immunogen:Anti-human CKMT1A mAb, clone PAT17A2AT, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CKMT1A protein 4-417 amino acids purified from E. coli.
Clone:PAT17A2AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:CKMT1A antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:CKMT1A is in charge of the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. CKMT1A is a member of the creatine kinase isoenzyme family and exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase arises in two different oligomeric forms: dimers and octamers, unlike the exclusively dimeric cytosolic creatine kinase isoenzymes. Numerous malignant cancers with poor prognosis have displayed overexpression of ubiquitous mitochondrial creatine kinase which is linked to high energy turnover and inability to remove cancer cells through apoptosis.
Synonyms:Creatine kinase mitochondrial 1A, creatine kinase mitochondrial 1 (ubiquitous), creatine kinase U-type mitochondrial, Acidic-type mitochondrial creatine kinase, Ubiquitous mitochondrial creatine kinase, CKMT1, U-MtCK, mia-CK, EC 2.7.3, EC 2.7.3.2.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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