The CKII Alpha Rabbit Monoclonal Antibody (CAB19683) is a specialized tool for researchers studying CKII Alpha, a key regulatory protein involved in cell signaling and protein phosphorylation processes. This antibody, generated in rabbits, is highly specific to human CKII Alpha and has been validated for use in Western blotting and immunohistochemistry applications.CKII Alpha is a catalytic subunit of the protein kinase CKII, which plays a critical role in modulating cell proliferation, apoptosis, and cell cycle regulation. Dysregulation of CKII Alpha has been linked to various diseases, including cancer, neurodegenerative disorders, and immune-related conditions.
By targeting CKII Alpha with this antibody, researchers can investigate its expression levels, subcellular localization, and interactions with other proteins in order to uncover its functional significance in disease pathways.This CKII Alpha Rabbit Monoclonal Antibody is an essential tool for scientists conducting research in the fields of cell biology, cancer biology, and signal transduction. Its high specificity and sensitivity make it an invaluable asset for exploring the intricate mechanisms underlying CKII Alpha signaling and its potential as a therapeutic target in various disease contexts.
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Multiple transcript variants encoding different protein isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1457
Clone Number:
ARC0163
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Casein Kinase 2 alpha (CSNK2A1) antibody (CAB19683) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
