The CISH Polyclonal Antibody (CAB14527) is a valuable tool for researchers studying CISH, a protein involved in immune regulation and signaling pathways. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the CISH protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in immunology, cancer research, and beyond.CISH, also known as cytokine-inducible SH2-containing protein, plays a crucial role in regulating the immune response by modulating cytokine signaling and downstream pathways. Its involvement in immune system balance and inflammation makes it a key player in the development of therapies for conditions such as autoimmune diseases, inflammatory disorders, and cancer.
Understanding the function of CISH is essential for advancing our knowledge of immune regulation and developing targeted treatments for related diseases.Overall, the CISH Polyclonal Antibody (CAB14527) is a valuable asset for researchers looking to explore the role of CISH in immune regulation and its implications for various disease states. Its high reactivity, specificity, and reliability make it an essential tool for advancing scientific understanding in the field of immunology.
Product Name:
CISH Rabbit Polyclonal Antibody
SKU:
CAB14527
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 17-130 of human CISH (NP_659508.1).
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1154
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CISH Rabbit pAb (CAB14527) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
