The CISD2 Polyclonal Antibody (CAB14168) is a highly specific tool for researchers studying CISD2, a protein involved in regulating cellular iron homeostasis and mitochondrial function. This antibody, produced in rabbits, has been validated for use in various applications, including Western blot and immunofluorescence.CISD2, also known as CDGSH iron-sulfur domain 2, plays a crucial role in maintaining proper iron levels within the cell, which is essential for mitochondrial function and overall cell health.
Dysregulation of CISD2 has been linked to various diseases, including neurodegenerative disorders and cancer.By using the CISD2 Polyclonal Antibody, researchers can accurately detect and analyze CISD2 protein levels in different cell types, aiding in the understanding of its function and potential therapeutic applications. This antibody is a valuable tool for investigating the role of CISD2 in mitochondrial biology, iron metabolism, and disease pathogenesis.
Product Name:
CISD2 Rabbit Polyclonal Antibody
SKU:
CAB14168
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 61-135 of human CISD2 (NP_001008389.1).
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2.
Purification Method:
Affinity purification
Gene ID:
493856
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CISD2 antibody (CAB14168) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
