The CIRH1A Polyclonal Antibody (CAB8593) is a valuable tool for researchers studying the CIRH1A protein, which is involved in cellular functions related to ribosome biogenesis and rRNA processing. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.CIRH1A plays a crucial role in maintaining cellular homeostasis by regulating the generation of ribosomes, which are essential for protein synthesis. Dysregulation of CIRH1A has been linked to various diseases, including cancer and developmental disorders. By targeting the CIRH1A protein, researchers can gain insight into its role in these pathological conditions and potentially identify therapeutic targets for intervention.
The CIRH1A Polyclonal Antibody is a reliable tool for detecting and analyzing the expression levels of CIRH1A in different cell types, making it an ideal choice for studies in cell biology and molecular biology. By understanding the functions of CIRH1A, researchers can advance their knowledge of cellular processes and potentially identify new strategies for treating diseases associated with CIRH1A dysregulation.
Product Name:
CIRH1A Rabbit Polyclonal Antibody
SKU:
CAB8593
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 497-686 of human CIRH1A (NP_116219.2).
This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
84916
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CIRH1A antibody (CAB8593) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
