The CIPC Antibody (PAC041582) is a polyclonal antibody designed for research involving the protein encoded by the CD300A gene. CD300A is a cell surface molecule that plays a crucial role in immune regulation, specifically inhibiting immune responses. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the CD300A protein, this antibody enables the detection and analysis of CD300A in various cell types, making it ideal for studies in immunology and cancer research.The CD300A protein, also known as an immune inhibitory receptor, is involved in regulating inflammation and inhibiting allergic reactions, ultimately contributing to immune homeostasis.
Its role in immune response modulation makes it a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the activity of CD300A is crucial for the development of therapies that harness or modulate immune function in these disease contexts.Overall, the CIPC Antibody (PAC041582) is a powerful tool for investigating the function of CD300A in the immune system, providing valuable insights for the development of novel therapeutic strategies in various disease settings.
Western blot. All lanes: CIPC antibody at 6µg/ml. Lane 1: A431 whole cell lysate. Lane 2: NIH/3T3 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 43 kDa. Observed band size: 43 kDa.
Immunohistochemistry of paraffin-embedded human stomach tissue using PACO41582 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human liver cancer using PACO41582 at dilution of 1:100.
Background:
Transcriptional repressor which acts as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. Stimulates ARNTL/BMAL1-dependent phosphorylation of CLOCK.
CIPC: Transcriptional repressor which acts as a negative- feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. Interacts with CLOCK. Forms a ternary complex with the CLOCK-ARNTL/BMAL1 heterodimerChromosomal Location of Human Ortholog: 14q24.3Cellular Component: nucleusMolecular Function: protein bindingBiological Process: negative regulation of circadian rhythm; negative regulation of transcription, DNA-dependent; rhythmic process; transcription, DNA-dependent
