CIITA Rabbit Polyclonal Antibody (CAB16401)
- SKU:
- CAB16401
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | CIITA Rabbit Polyclonal Antibody |
SKU: | CAB16401 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 650-750 of human CIITA (NP_000237.2). |
Sequence: | LDSP PGAL AELA KLAW ELGR RHQS TLQE DQFP SADV RTWA MAKG LVQH PPRA AESE LAFP SFLL QCFL GALW LALS GEIK DKEL PQYL ALTP RKKR PYDN W |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | C2TA; NLRA; MHC2TA; CIITAIV; CIITA |
Positive Sample: | K-562,rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus, PML body. |
Calculated MW: | 124kDa |
Observed MW: | 150kDa |
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 4261 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |