The CIITA Polyclonal Antibody (CAB16401) is a valuable tool for researchers studying the Class II Major Histocompatibility Complex Transactivator (CIITA), a key regulator of immune response. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the CIITA protein, researchers can effectively study its expression and activity in different cell types, providing valuable insights into immune regulation and immune-mediated diseases.CIITA is essential for the transcriptional activation of MHC class II genes, playing a critical role in antigen presentation and adaptive immune responses.
Dysregulation of CIITA expression has been implicated in various autoimmune diseases, infections, and cancer. Therefore, understanding the mechanisms underlying CIITA function is crucial for developing targeted therapies and vaccines.In summary, the CIITA Polyclonal Antibody is a reliable tool for investigating the role of CIITA in immune regulation and disease pathogenesis. Its high specificity and sensitivity make it ideal for research in immunology, infectious diseases, and oncology, offering valuable insights into potential therapeutic strategies for immune-related disorders.
Product Name:
CIITA Rabbit Polyclonal Antibody
SKU:
CAB16401
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 650-750 of human CIITA (NP_000237.2).
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4261
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CIITA Rabbit pAb (CAB16401) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
