CIC Rabbit Polyclonal Antibody (CAB15408)
- SKU:
- CAB15408
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | CIC Rabbit Polyclonal Antibody |
SKU: | CAB15408 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1379-1608 of human CIC (NP_055940.3). |
Sequence: | LATS PRAI LGSY RKKR KNST DLDS APED PTSP KRKM RRRS SCSS EPNT PKSA KCEG DIFT FDRT GTEA EDVL GELE YDKV PYSS LRRT LDQR RALV MQLF QDHG FFPS AQAT AAFQ ARYA DIFP SKVC LQLK IREV RQKI MQAA TPTE QPPG AEAP LPVP PPTG TAAA PAPT PSPA GGPD PTSP SSDS GTAQ AAPP LPPP PESG PGQP GWEG APQP SPPP PGPS TAAT GR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 |
Synonyms: | MRD45; CIC |
Positive Sample: | NIH/3T3 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 164kDa |
Observed MW: | 164kDa |
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 23152 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |