The CIC Polyclonal Antibody (CAB15408) is a valuable tool for researchers studying the CIC protein, which is involved in various cellular processes including cell growth, differentiation, and apoptosis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CIC protein, this antibody allows for the detection and analysis of CIC expression in a variety of cell types, making it ideal for studies in molecular biology and cancer research.CIC is a transcription factor that acts as a tumor suppressor in various cancers, including gliomas and lung cancer.
Its role in regulating gene expression and cell proliferation makes it a promising target for therapeutic interventions. By gaining a better understanding of the function of CIC, researchers can uncover new strategies for treating cancer and other diseases associated with dysregulated cell growth. The CIC Polyclonal Antibody is a valuable tool for advancing research in this area and exploring the potential clinical applications of targeting the CIC protein.
Product Name:
CIC Rabbit Polyclonal Antibody
SKU:
CAB15408
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1379-1608 of human CIC (NP_055940.3).
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
23152
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells, using CIC Rabbit pAb (CAB15408) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
