The CIB1 Polyclonal Antibody (CAB4430) is a research tool designed for studying CIB1, a calcium and integrin-binding protein involved in cell adhesion and migration. This antibody, generated in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By targeting the CIB1 protein, this antibody allows for the detection and analysis of CIB1 in various cell types, making it an ideal tool for research in cell biology and cancer biology.
CIB1, also known as Calmyrin, plays a critical role in mediating cellular functions such as adhesion, migration, and cytoskeletal organization. Its involvement in signaling pathways related to cancer progression and metastasis highlights its importance as a potential therapeutic target. By elucidating the functions of CIB1, researchers can gain valuable insights into the mechanisms underlying cancer development and potentially identify new treatment strategies.
Product Name:
[KO Validated] CIB1 Rabbit Polyclonal Antibody
SKU:
CAB4430
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-191 of human CIB1 (NP_006375.2).
This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10519
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CIB1 antibody (CAB4430) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
