The CHTF18 Polyclonal Antibody (CAB17752) is a high-quality antibody designed for research involving CHTF18, a key protein involved in DNA repair and maintenance. This rabbit polyclonal antibody is highly reactive with human samples and is validated for use in Western blot applications. By specifically binding to the CHTF18 protein, this antibody allows for accurate detection and analysis in various cell types, making it a valuable tool for studies in genetics, oncology, and DNA damage response research.
CHTF18 is known for its role in maintaining genomic stability and ensuring proper DNA replication, making it a crucial player in preventing mutations and genomic instability. Dysregulation of CHTF18 has been linked to various diseases, including cancer and genetic disorders, highlighting the importance of studying its function. By understanding the mechanisms by which CHTF18 works, researchers can uncover potential targets for therapeutic interventions in diseases related to DNA repair and replication.
Product Name:
CHTF18 Rabbit Polyclonal Antibody
SKU:
CAB17752
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 794-975 of human CHTF18 (NP_071375.1).
This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition.
Purification Method:
Affinity purification
Gene ID:
63922
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using CHTF18 Rabbit pAb (CAB17752) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
