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CHSY1 Antibody (PACO00602)

SKU:
PACO00602
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323
Frequently bought together:

Description

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Antibody Name:CHSY1 Antibody
Antibody SKU:PACO00602
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human CHSY1.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CHSY1; CHSY; CSS1; KIAA0990; Chondroitin sulfate synthase 1; Chondroitin glucuronyltransferase 1; Chondroitin synthase 1; ChSy-1; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1; N-acetylgalactosa
UniProt Protein Function:CHSY1: Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Involved in the negative control of osteogenesis likely through the modulation of NOTCH signaling. Defects in CHSY1 are the cause of Temtamy preaxial brachydactyly syndrome (TPBS). A syndrome characterized by multiple congenital anomalies, mental retardation, sensorineural deafness, talon cusps of upper central incisors, growth retardation, and bilateral symmetric digital anomalies mainly in the form of preaxial brachydactyly and hyperphalangism. Belongs to the chondroitin N- acetylgalactosaminyltransferase family.
UniProt Protein Details:

Protein type:Transferase; EC 2.4.1.175; Membrane protein, integral; Glycan Metabolism - chondroitin sulfate biosynthesis; EC 2.4.1.226

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: extracellular region; Golgi membrane; membrane

Molecular Function:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity

Biological Process: chondroitin sulfate biosynthetic process; negative regulation of ossification

Disease: Temtamy Preaxial Brachydactyly Syndrome

NCBI Summary:This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome. [provided by RefSeq, Dec 2011]
UniProt Code:Q86X52
NCBI GenInfo Identifier:116241296
NCBI Gene ID:22856
NCBI Accession:Q86X52.3
UniProt Secondary Accession:Q86X52,Q6UX38, Q7LFU5, Q9Y2J5,
UniProt Related Accession:Q86X52
Molecular Weight:91,784 Da
NCBI Full Name:Chondroitin sulfate synthase 1
NCBI Synonym Full Names:chondroitin sulfate synthase 1
NCBI Official Symbol:CHSY1  
NCBI Official Synonym Symbols:CHSY; CSS1; TPBS; ChSy-1  
NCBI Protein Information:chondroitin sulfate synthase 1
UniProt Protein Name:Chondroitin sulfate synthase 1
UniProt Synonym Protein Names:Chondroitin glucuronyltransferase 1; Chondroitin synthase 1; ChSy-1; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase 1; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1; N-acetylgalactosaminyltransferase 1
Protein Family:Chondroitin sulfate synthase
UniProt Gene Name:CHSY1  
UniProt Entry Name:CHSS1_HUMAN

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