| UniProt Protein Function: | CHST9: Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin. Belongs to the sulfotransferase 2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transferase; Membrane protein, integral; EC 2.8.2.-Chromosomal Location of Human Ortholog: 18q11.2Cellular Component: Golgi membraneMolecular Function: chondroitin 4-sulfotransferase activity; N-acetylgalactosamine 4-O-sulfotransferase activityBiological Process: chondroitin sulfate biosynthetic process; hormone biosynthetic process; proteoglycan biosynthetic process; sulfur metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q7L1S5 |
| NCBI GenInfo Identifier: | 229462829 |
| NCBI Gene ID: | 83539 |
| NCBI Accession: | Q7L1S5.2 |
| UniProt Secondary Accession: | Q7L1S5,Q6UX69, Q9BXH3, Q9BXH4, Q9BZW9 |
| UniProt Related Accession: | Q7L1S5 |
| Molecular Weight: | 8,591 Da |
| NCBI Full Name: | Carbohydrate sulfotransferase 9 |
| NCBI Synonym Full Names: | carbohydrate sulfotransferase 9 |
| NCBI Official Symbol: | CHST9Â Â |
| NCBI Official Synonym Symbols: | GalNAc4ST2; GALNAC4ST-2Â Â |
| NCBI Protein Information: | carbohydrate sulfotransferase 9 |
| UniProt Protein Name: | Carbohydrate sulfotransferase 9 |
| UniProt Synonym Protein Names: | GalNAc-4-O-sulfotransferase 2; GalNAc-4-ST2; GalNAc4ST-2; N-acetylgalactosamine-4-O-sulfotransferase 2 |
| Protein Family: | Carbohydrate sulfotransferase |
| UniProt Gene Name: | CHST9Â Â |
| UniProt Entry Name: | CHST9_HUMAN |
