The CHST9 Antibody (PACO08430) is a polyclonal antibody specifically designed for research involving CHST9, a key enzyme involved in the biosynthesis of chondroitin sulfate. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for a wide range of research applications.CHST9 plays a crucial role in the modification of proteins and the regulation of cellular processes, particularly in the development and maintenance of cartilage and other connective tissues. By targeting CHST9 with this antibody, researchers can effectively study its function and role in various biological processes.Validated for use in Western blot applications, this antibody enables the detection and analysis of CHST9 protein in different cell types and tissues.
Its high specificity and sensitivity make it a valuable tool for studies in biochemistry, molecular biology, and developmental biology, providing valuable insights into the complex mechanisms of chondroitin sulfate biosynthesis.Overall, the CHST9 Antibody (PACO08430) is a reliable and effective tool for researchers seeking to explore the functions and mechanisms of CHST9 in various biological processes, making it a valuable asset in the fields of glycoscience, regenerative medicine, and tissue engineering.
CHST9: Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin. Belongs to the sulfotransferase 2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transferase; Membrane protein, integral; EC 2.8.2.-Chromosomal Location of Human Ortholog: 18q11.2Cellular Component: Golgi membraneMolecular Function: chondroitin 4-sulfotransferase activity; N-acetylgalactosamine 4-O-sulfotransferase activityBiological Process: chondroitin sulfate biosynthetic process; hormone biosynthetic process; proteoglycan biosynthetic process; sulfur metabolic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Sulfate groups on carbohydrates confer highly specific functions to glycoproteins, glycolipids, and proteoglycans, and are critical for cell-cell interaction, signal transduction, and embryonic development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Aug 2011]
