Anti-CHST5 Antibody (CAB17667)
- SKU:
- CAB17667
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-CHST5 Antibody (CAB17667)
The CHST5 Polyclonal Antibody (CAB17667) is a valuable tool for researchers studying CHST5, an enzyme involved in the biosynthesis of chondroitin sulfate, a key component of the extracellular matrix. This antibody, raised in rabbits, is highly specific and sensitive for detecting CHST5 in human samples, making it ideal for use in applications such as Western blotting.CHST5 plays a crucial role in the modification of proteoglycans, which are essential for various biological processes including cell adhesion, migration, and signaling.
Dysregulation of CHST5 has been implicated in diseases such as cancer and musculoskeletal disorders, making it a promising target for therapeutic interventions.By utilizing the CHST5 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of CHST5 in both normal and pathological conditions. This antibody enables the precise detection and analysis of CHST5 expression in different cell types, providing a deeper understanding of its involvement in disease processes.
| Antibody Name: | Anti-CHST5 Antibody |
| Antibody SKU: | CAB17667 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 232-411 of human CHST5 (NP_078809.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HT-29 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 232-411 of human CHST5 (NP_078809.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SREA AGPI LARD NGIV LGTN GKWV EADP HLRL IREV CRSH VRIA EAAT LKPP PFLR GRYR LVRF EDLA REPL AEIR ALYA FTGL TLTP QLEA WIHN ITHG SGIG KPIE AFHT SSRN ARNV SQAW RHAL PFTK ILRV QEVC AGAL QLLG YRPV YSAD QQRD LTLD LVLP RGPD HFSW ASPD |
| Gene ID: | 23563 |
| Uniprot: | Q9GZS9 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 46kDa |
 | Western blot - CHST5 Polyclonal Antibody (CAB17667) |
| Synonyms: | I-GlcNAc-6-ST, I-GlcNAc6ST, glcNAc6ST-3, gn6st-3, hIGn6ST, CHST5 |
| Background: | The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011] |
| UniProt Protein Function: | CHST5: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.8.2.-; Membrane protein, integral Chromosomal Location of Human Ortholog: 16q22.3 Cellular Component: Golgi apparatus; Golgi membrane Molecular Function:N-acetylglucosamine 6-O-sulfotransferase activity; sulfotransferase activity Biological Process: keratan sulfate biosynthetic process; N-acetylglucosamine metabolic process; protein amino acid sulfation; sulfur metabolic process |
| NCBI Summary: | The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9GZS9 |
| NCBI GenInfo Identifier: | 239938912 |
| NCBI Gene ID: | 23563 |
| NCBI Accession: | Q9GZS9.3 |
| UniProt Secondary Accession: | Q9GZS9,Q7LCN3, Q9UBY3, B2RV23, |
| UniProt Related Accession: | Q9GZS9 |
| Molecular Weight: | 46,894 Da |
| NCBI Full Name: | Carbohydrate sulfotransferase 5 |
| NCBI Synonym Full Names: | carbohydrate sulfotransferase 5 |
| NCBI Official Symbol: | CHST5Â Â |
| NCBI Official Synonym Symbols: | gn6st-3; hIGn6ST; I-GlcNAc6ST; glcNAc6ST-3; I-GlcNAc-6-STÂ Â |
| NCBI Protein Information: | carbohydrate sulfotransferase 5 |
| UniProt Protein Name: | Carbohydrate sulfotransferase 5 |
| UniProt Synonym Protein Names: | Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha; GST4-alpha; Intestinal N-acetylglucosamine-6-O-sulfotransferase; I-GlcNAc6ST; Intestinal GlcNAc-6-sulfotransferase; hIGn6ST; N-acetylglucosamine 6-O-sulfotransferase 3; GlcNAc6ST-3; Gn6st-3 |
| Protein Family: | Carbohydrate sulfotransferase |
| UniProt Gene Name: | CHST5Â Â |
| UniProt Entry Name: | CHST5_HUMAN |
Related Products
Anti-CREB1 Antibody (CAB11063)
Anti-NUR77 Antibody (CAB0843)
Anti-HDAC6 Antibody (CAB11429)
Anti-GSK3Beta Antibody (CAB11360)
Anti-SQSTM1 Antibody (CAB11246)
