The CHST13 Polyclonal Antibody (PACO02575) is a valuable tool for researchers studying the CHST13 protein, which plays a key role in the sulfation of glycosaminoglycans and is involved in various cellular processes, including cell adhesion and migration. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.The CHST13 Polyclonal Antibody binds specifically to the CHST13 protein, allowing for detection and analysis in a variety of cell types. Its versatility and accuracy make it an excellent choice for studies in glycobiology, cell biology, and cancer research.
CHST13, also known as carbohydrate sulfotransferase 13, is a critical enzyme involved in the biosynthesis of sulfated glycosaminoglycans, which are essential components of the extracellular matrix and play important roles in cell signaling and tissue development. Dysregulation of CHST13 has been implicated in various diseases, making it a promising target for therapeutic interventions.For researchers interested in understanding the role of CHST13 in health and disease, the CHST13 Polyclonal Antibody is an invaluable tool for detecting and studying this important protein in diverse experimental settings.
Antibody Name:
CHST13 Antibody
Antibody SKU:
PACO02575
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human CHST13.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
CHST13: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan. Belongs to the sulfotransferase 2 family.Protein type: EC 2.8.2.5; Membrane protein, integral; Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Energy Metabolism - sulfurChromosomal Location of Human Ortholog: 3q21.3Cellular Component: Golgi membrane; integral to membraneMolecular Function: chondroitin 4-sulfotransferase activity; N-acetylgalactosamine 4-O-sulfotransferase activityBiological Process: carbohydrate biosynthetic process; carbohydrate metabolic process; chondroitin sulfate biosynthetic process; chondroitin sulfate metabolic process; glycosaminoglycan metabolic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. [provided by RefSeq, Aug 2011]
