The CHST11 Polyclonal Antibody (CAB13734) is a valuable tool for researchers studying CHST11, an enzyme involved in the biosynthesis of chondroitin sulfate, a major component of the extracellular matrix. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the CHST11 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for investigations in the fields of glycobiology and cartilage biology.CHST11, also known as chondroitin-4-sulfotransferase 1, plays a crucial role in the modification of chondroitin sulfate chains, which are essential for proper cell signaling and tissue development.
Dysregulation of CHST11 has been implicated in various diseases, including cancer and inflammatory disorders, highlighting its importance as a potential therapeutic target. By studying the function of CHST11, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially develop new treatment strategies aimed at modulating chondroitin sulfate biosynthesis.
Product Name:
CHST11 Rabbit Polyclonal Antibody
SKU:
CAB13734
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 38-352 of human CHST11 (NP_060883.1).
Golgi apparatus membrane, Single-pass type II membrane protein.
Calculated MW:
42kDa
Observed MW:
42kDa
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
50515
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CHST11 Rabbit pAb (CAB13734) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
