The CHRNG Polyclonal Antibody (CAB7884) is a valuable tool for researchers studying the CHRNG gene, which encodes the acetylcholine receptor subunit gamma involved in muscle function. This polyclonal antibody, raised in rabbits, is highly specific for human samples and suitable for use in Western blot applications. By binding to the CHRNG protein, this antibody allows for the detection and analysis of CHRNG expression in various tissues and cell types.The CHRNG gene is essential for neuromuscular transmission and muscle contraction, making it a key target for research into neuromuscular disorders, myasthenia gravis, and other conditions affecting muscle function.
Understanding the expression and function of CHRNG is crucial for developing targeted therapies and interventions for these conditions. The CHRNG Polyclonal Antibody (CAB7884) is a valuable tool for investigating the role of CHRNG in health and disease.
Product Name:
CHRNG Rabbit Polyclonal Antibody
SKU:
CAB7884
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 328-517 of human CHRNG (NP_005190.4).
The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.
Purification Method:
Affinity purification
Gene ID:
1146
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CHRNG antibody (CAB7884) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
