The CHRNB1 Polyclonal Antibody (CAB5295) is a valuable tool for researchers studying the CHRNB1 protein, which is a subunit of the neuronal nicotinic acetylcholine receptor. This receptor plays a crucial role in neurotransmission and has been implicated in various neurological disorders.Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to CHRNB1, the antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in neurobiology and neuroscience.
The CHRNB1 protein is involved in mediating the effects of nicotine and other neurotransmitters in the brain, making it a potential target for drug development in addiction and other neurological conditions. Research on CHRNB1 with the use of this antibody may provide valuable insights into the underlying mechanisms of these disorders and aid in the development of novel therapeutic strategies.
Product Name:
CHRNB1 Rabbit Polyclonal Antibody
SKU:
CAB5295
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-235 of human CHRNB1 (NP_000738.2).
The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome.
Purification Method:
Affinity purification
Gene ID:
1140
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CHRNB1 antibody (CAB5295) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
